2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2021
    Phosphoramidon 36357-77-4 98%
    Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
    Phosphoramidon
  • HY-N2940
    Bisandrographolide A 160498-00-0 98%
    Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound.
    Bisandrographolide A
  • HY-N3047
    Piperolactam C 116064-76-7 98%
    Piperolactam C (O-Methylpiperolactam B) is a natural alkaloid with anti-platelet aggregation effects.
    Piperolactam C
  • HY-N3054
    Pinusolidic acid 40433-82-7 98%
    Pinusolidic acid is a platelet-activating factor (PAF) inhibitor with an IC50 of 23 μM.
    Pinusolidic acid
  • HY-N3618
    Conopharyngine 76-98-2 98%
    Conopharyngine (12,13-Dimethoxycoronaridine) is the indole-alkaloid that can be isolated from Tabernaemontana pachysiphon. Conopharyngine affects the functions of cardiovascular and smooth muscle, and exhibits analgesic and nervous system stimulating activity.
    Conopharyngine
  • HY-N3704
    Δ16-Dehydroadynerigenin β-D-digitaloside 52628-62-3 98%
    Δ16-Dehydroadynerigenin β-D-digitaloside is a glycoside that can be isolated from the oven dried leaves of Nerium odorum. It is a heart-healthy component.
    Δ16-Dehydroadynerigenin β-D-digitaloside
  • HY-N5170
    Aselacin A 156223-06-2 98%
    Aselacin A targets endothelin-1 receptor (ET-1 receptor), inhibits the the binding of ET-1 to ETA receptor and ETB receptor. Aselacin A inhibits the ET-1 binding to bovine atrial membrane and porcine cerebral membrane with IC50 of 22 μg/mL and 20 μg/mL. Aselacin A can be used for research of cardiovascular diseases.
    Aselacin A
  • HY-N5171
    Aselacin B 156223-07-3 98%
    Aselacin B targets endothelin-1 receptor (ET-1 receptor), inhibits the the binding of ET-1 to ETA receptor and ETB receptor. Aselacin B can be used for research of cardiovascular diseases.
    Aselacin B
  • HY-N7488
    Visnadine 477-32-7 98%
    Visnadine is a natural product that can be isolated from bishop's weed. Visnadine is a vasodilator.
    Visnadine
  • HY-N8380
    (-)-Latifolin 10154-42-4 98%
    (-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.
    (-)-Latifolin
  • HY-N8735
    k-Strophanthoside 33279-57-1 98%
    k-Strophanthoside is a cardiac glycoside compound that can be isolated from the seeds of Strophanthus kombe.
    k-Strophanthoside
  • HY-N9422
    Adenosine 3'-phosphate 5'-phosphosulfate triethylamine 936827-87-1 98%
    Adenosine 3'-phosphate 5'-phosphosulfate triethylamine, is a universal sulfuryl donor for sulfation. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine (PAPS) is synthesized in the cytosol and subsequently translocated into the Golgi lumen via a PAPS transporter (PAPST).
    Adenosine 3'-phosphate 5'-phosphosulfate triethylamine
  • HY-N9520
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone 120693-52-9 98%
    Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
  • HY-NP171
    DSPE-PCB 98%
    DSPE-PCB is a lipid mixture that combines the properties of DSPE and zwitterionic polycarboxybetaine (PCB) and can be used for liposome preparation.
    DSPE-PCB
  • HY-P1168
    [Orn8]-Urotensin II (human) 479065-85-5 98%
    [Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293.
    [Orn8]-Urotensin II (human)
  • HY-P2072
    GF109 79873-93-1 98%
    GF109 is a potent parenteral inhibitor of angiotensin converting enzyme (ACE). GF109 has antihypertensive effects.
    GF109
  • HY-P3269
    Calciseptine 178805-91-9 98%
    Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].
    Calciseptine
  • HY-P4551
    Hippuryl-His-Leu-OH 31373-65-6 98%
    Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection.
    Hippuryl-His-Leu-OH
  • HY-P5006
    (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin 176714-12-8 98%
    (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) is a specific antagonist of vasopressin V1a receptor, with a pA2 of 6.71.
    (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin
  • HY-Z3151
    3'-(2-Fluorophenyl) ezetimibe 1798008-25-9 98%
    3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor Ezetimibe (HY-17376).
    3'-(2-Fluorophenyl) ezetimibe
Cat. No. Product Name / Synonyms Application Reactivity